In human acute myeloid leukemia (AML) cell line models, 1,25-dihydroxyvitamin D3 induces monocytic differentiation and CD14 expression, an effect that is mediated through activation of MEF2C signaling via regulation of CCAAT-/enhancer-binding protein alpha (CEBPA) [6]. Here, MEF2C is linked to acute myeloid leukemia.