IFT54 and retinal degeneration: Previous loss-of-function studies have also shown the importance of this anterograde IFT subunit, as loss of Traf3ip1 is embryonic lethal with attendant neural, skeletal and ocular defects in mice, and loss of cilia, retinal degeneration, body axis curvature and pronephric cysts in elipsa mutant zebrafish11, 12, 13.