For example, fast N-type inactivation induced by Kvβ1.1 is linked to autosomal dominant lateral temporal lobe epilepsy29, such that Ca2+/CaM-mediated modulation of Kv1.4/Kvβ1.1 and Kv1.1/Kvβ1.1 might have the potential to reduce the severity of epileptic seizures. The gene discussed is KCNA1; the disease is Seizure.