Quantitative and qualitative lipidomic analysis of the impact of statin treatment on our mixed dyslipidemic subjects with MetS who exhibited a prediabetic state at baseline has emphatically demonstrated extensive pleiotropic impact on circulating lipids beyond atherogenic apoB-containing lipoproteins and LDL-C, thereby revealing modulation of lipid levels which are otherwise undetected by standard plasma lipid assays and are potentially clinically relevant. The gene discussed is APOB; the disease is metabolic syndrome.