Comparison of the plasma lipidome in large cohorts of healthy, prediabetic, and T2D individuals displaying mixed dyslipidemia with those of normal glucose-tolerant normolipidemic subjects by mass spectrometric analysis has identified significant associations between specific plasma lipid classes and insulin-resistant states, i.e., prediabetes and T2D (17, 18). The gene discussed is INS; the disease is metabolic syndrome.