CD4 and cervical cancer: In particular, cervical cancer, which still remains as one of the most common malignant tumors among women in the developing world [25, 26], is predominantly controlled by functional cellular immunity under the action of both CD4+ and CD8+ T cells [27, 28]; however, these tumors have been characterized by apparent contradictions in the immune response [29–32], which could be partially explained by the action of specific CD4+ T cell subsets.