evaluated the acceptability and accuracy of Cytosponge in the primary care setting in a cohort study of 501 patients from the United Kingdom and showed that Cytosponge with TFF3 IHC had sensitivity and specificity of 73% and 94%, respectively, for diagnosing 1 cm or longer circumferential BE segments, which further increased to 90% and 93.5%, respectively, for circumferential BE segments 2 cm or longer [17]. Here, TFF3 is linked to Barrett esophagus.