NPM1 and acute myeloid leukemia: Our results of the sorted cell populations confirm the molecular heterogeneity of hematopoietic clones at complete remission Liran et al. [20] also reported the presence of DNMT3A mutations at a high allelic frequency in highly purified HSCs, progenitors and mature blood cell fractions in AML patients in complete remission but did not observe concurrent NPM1 mutations, present in the blast cells at AML diagnosis.