PIK3CA and non-small cell lung carcinoma: However, it is to be noted that the experiments with Akt2 shRNAs or pharmacological inhibitors, indicate that aberrant signalling through the PI3K/Akt pathway in NSCLC TICs is funnelled through the diverse Akt isoforms, and thus that efficient suppression of all isoforms is required for the eventual eradication of NSCLC TICs.