Silencing of STAT3 with two different shRNAs (Supplemental Figure S6B, clones #1 and #2, respectively) or pharmacological inhibitors (Sta-21 and Stat3 Inhibitor XIII) produced a significant decrease in the number and in the size of LCSs generated by NSCLC cells (Figure 7C–7E) and impaired tumor growth in mice (n = 5/group) (Figure 7F). This evidence concerns the gene STAT3 and non-small cell lung carcinoma.