As to the mechanism, our data indicate that Akt regulates IL-6 production in NSCLC cells by inducing IkB degradation, which allows NF-kB to enter the nucleus and activate IL-6 transcription [61, 62] and, on the other hand, that a critical effector of IL-6 is STAT3. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.