Akt activation was observed in 32 out of 96 NSCLC (13/45 ADC, 11/32 SCC, 8/19 tumors with other histotypes, respectively) as already reported [19]; IL-6 expression was observed in 38 out of 102 NSCLC analysed (18/49 ADC, in 13/34 SCC and in 7/19 tumors with other histotypes); STAT3 activation was observed in 36 out of 99 NSCLC analysed (19/46 ADC, 10/33 SCC, 7/20 tumors with other histotypes). This evidence concerns the gene AKT1 and AIDS dementia complex.