Silencing of Akt1 in NCI-H460 and PEd/10, as assessed by immunoblot (Supplemental Figure S3A), resulted in reduced expansion of tumors generated by NSCLC cells injected into immunodeficient mice (n = 5/group) (Supplemental Figure S3B and S3C, respectively), indicating that Akt1 plays a significant role in the malignant behaviour of NSCLC cells. Here, AKT1 is linked to non-small cell lung carcinoma.