However, it is to be noted that the experiments with Akt2 shRNAs or pharmacological inhibitors, indicate that aberrant signalling through the PI3K/Akt pathway in NSCLC TICs is funnelled through the diverse Akt isoforms, and thus that efficient suppression of all isoforms is required for the eventual eradication of NSCLC TICs. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.