TP53 and familial pancreatic carcinoma: The activation of p21WAF1/CIP1 by CGK733 is the Gemcitabine-resistant pancreatic cancer cell lines tested is very interesting as p21WAF1/CIP1 is known to be involved in mediating p53-dependent cell cycle arrest following DNA damage [20–22] but can also inhibit apoptosis [23–27].