Interestingly, this patient as well as 3 other unrelated individuals (Patients 117197, 126002, and 129413) all had the same non-rare variant in BRCA1, p.Q356R, which some prior studies have linked to prostate cancer risk [63]; an observed incidence of 33%, versus the expected incidence of this variant should be 9%, based on ExAC. The gene discussed is BRCA1; the disease is prostate cancer.