Potentially magnifying the effect of the PALB2 truncation, this patient also has a mutation (p.R101Q) predicted to damage in the ubiquitin conjugating enzyme UBE2V2, identified as a factor required for avoidance of UV damage [44], with expression of UBE2V2 linked to prognosis in breast cancers following treatment with DNA damaging therapies [45]. The gene discussed is UBE2V2; the disease is breast cancer.