Among genes differentially expressed between tumor samples with and without necrosis, a substantial number of hypoxia-related genes were found to be up-regulated, such as IL6, CXCL8 (IL8), SERPINE1 as well as genes involved in glycolysis (SLC2A3, LDHA) (Table 2 and Supplementary Table S2). Here, LDHA is linked to neoplasm.