Vieweg et al. demonstrated that only E-cadherin positive (E-cad+) cell subpopulations expressed high levels of the embryonic stem cell markers (SOX2, OCT3/4, Nanog, Klf4 and c-Myc), formed colonies, and grew as spheres under non-adherent conditions in prostate cancer [26]. Here, KLF4 is linked to Familial prostate cancer.