Prominently among these changes, CD62Lhi lateM cells showed increased expression of cytokine receptors including Il2rb and IL15ra (encoding IL-2Rβ and IL-15Rα respectively), and decreased expression of killer-cell lectin-like receptors including Klrg1. Furthermore, lateM cells showed alterations in genes regulating cell cycle progression and ribosome biogenesis, suggesting that the proliferative potential of memory CD8 T cells may increase with time after infection not only at the population level (Fig 2), but also within defined subsets. This evidence concerns the gene CD8A and infection.