KIAA0586 and ciliopathy: The body curvature phenotype was absent in the splice morphants, which may be explained either by rescue of this early phenotype by maternal ninl mRNA, which remains unaffected by splice morpholinos (as seen in some ciliopathy zebrafish mutants such as talpid3 where only the maternal zygotic mutants have a curved body shape [32]), or by less efficient gene knockdown with this morpholino, as normal transcript persists in addition to the aberrant transcript (S5c Fig).