While RAB8A was found to bind several ciliopathy proteins directly including CEP290 and RGPR [48,49], no direct interaction has been demonstrated between CC2D2A and RAB8A, despite a functional interaction in zebrafish photoreceptors and a requirement for CC2D2A in RAB8A localization in mouse embryonic fibroblasts [24,25]. The gene discussed is CEP290; the disease is ciliopathy.