We tested this by performing gene-based association analysis,17 with molecules implicated in eIF2 signaling (corresponding to proteins and mRNA transcripts implicated in eIF2 signaling; Table 1) using genome-wide association data based on >13 000 schizophrenia cases and >18 000 controls.14 Two proteins showed a significant association with schizophrenia, EIF2AK2 (P=3 × 10−6) and RPS13 (P=0.00029), following Bonferroni correction (P-value 0.05/48 genes tested=significance required P<0.0010; Supplementary Data set 5). The gene discussed is EIF2AK2; the disease is schizophrenia.