INSIG is a negative regulator of SCAP/SREBP.7 In response to the inhibition of INSIG, SCAP is released to escort SREBP to the Golgi apparatus for activation.8 In support of the previous findings that the INSIG-2 gene may be associated with MetS in SZ patients following antipsychotics treatment,9, 10 our present data provide further evidence that the protein INSIG-2 rather than INSIG-1 was suppressed in the rat liver after treatment with either CLO or RIS (Figures 2a and 3b, c). Here, INSIG2 is linked to metabolic syndrome.