TNFAIP3 and central nervous system cancer: Moreover, A20 plays an oncogenic role, as indicated by A20 overexpression in several malignancies, such as undifferentiated nasopharyngeal carcinoma, poorly differentiated head and neck squamous cell carcinoma [25], glioma [26, 27], glioblastoma [28], inflammatory breast cancer [29], and hepatocellular carcinoma [30].