Interestingly, the inverse correlation between A20 overexpression and SOCS3 repression discovered in our study suggests that the mechanism of SOCS3 downregulation in CCA may be similar to that reported in a previous study of liver regeneration [24], which showed that A20 enhanced JAK/STAT signals in hepatocytes by downregulating SOCS3 in the process of liver regeneration. Here, SOCS3 is linked to cholangiocarcinoma.