SOCS3 and neoplasm: As shown in Table 2, the results indicated that tumor differentiation (P = 0.026), lymph node metastasis (P = 0.004), vascular invasion (P < 0.001), TNM stage (P = 0.008), SOCS3 expression (P = 0.001) and A20 expression (P < 0.001) were prognostic factors with statistical significance (Table 2).