In the 86 CCA samples, 6 (7.0%) showed high expression of both SOCS3 and A20, 9 (10.5%) showed low expression of both SOCS3 and A20, 53 (61.6%) showed high A20 and low SOCS3 expression, and 18 (20.9%) showed low A20 and high SOCS3 expression. Here, TNFAIP3 is linked to cholangiocarcinoma.