As presented in Table 3, only lymph node metastasis (P = 0.007; HR, 1.142), vascular invasion (P = 0.001; HR, 1.370), SOCS3 expression (P = 0.022; HR, 2.382) and A20 expression (P = 0.009; HR, 6.598) served as independent biomarkers for prognosis, indicating that from all 13 biomarkers, a low SOCS3 level and high A20 level may represent the best prognostic indicators of survival in CCA. Here, SOCS3 is linked to cholangiocarcinoma.