MAS1 and colon adenocarcinoma: These findings are not surprising as (1) MAS is reported to be involved in ischemic-reperfusion injury in heart which is an event primarily mediated by cell-cell junction signaling [20,21,53] and (2) MAS was discovered as an oncogene and several studies report transformation of cells overexpressing MAS including up-regulation of MAS in human colon adenocarcinoma [2–5,54,55].