Comparison of the three cohorts with the large number of cancer sequencing projects (n = ~70) available on the cBio Portal [6,7] website were assessed using cBio Portal software and demonstrated that these three cohorts represent the three highest mutation frequencies of PBRM1 mutation, the 3rd to 5th highest mutation frequencies of BAP1 mutation and the 2nd, 3rd and 7th highest mutation frequencies of KDM5C mutation (Fig 2). This evidence concerns the gene KDM5C and cancer.