While several of these most commonly mutated chromatin remodeling/modifier genes are present on chromosome 3p, a chromosomal region that is lost in a high percentage of CCRCC tumors, three of these genes, KDM5C (JARID1C), KDM6A (UTX) and STAG2, are located on the X chromosome [2,5]. The gene discussed is KDM6A; the disease is nonpapillary renal cell carcinoma.