GSDMB and inflammatory bowel disease: A negative correlation between GSDMB expression and the number of susceptibility alleles was also present in the noninflamed, non-IBD ileal and colonic biopsy samples (Table 2, Figure 4), and the expression was lower at least 1.84-fold in individuals homozygous for the IBD susceptibility allele compared with that in individuals homozygous for the opposite allele.