Additionally, the susceptibility allele was associated with the increased expression of GSDMA and LRRC3C in noninflamed colon biopsies from individuals without IBD and with the reduced expression of PGAP3 and ZPBP2 in noninflamed ileum biopsies from individuals in the overall IBD cohort and the CD cohort, respectively. This evidence concerns the gene ZPBP2 and inflammatory bowel disease.