Furthermore, the IBD susceptibility allele was associated with the increased expression of GSDMA and LLRC3C in noninflamed, non-IBD colonic samples (Table 2, Figure 5) and with expression levels increased 5.53-fold and 6.78-fold, respectively, in individuals homozygous for the susceptibility allele compared with those in individuals homozygous for the opposite allele. The gene discussed is GSDMA; the disease is inflammatory bowel disease.