MIEN1 and carcinoma: Also, Pgap3 knockout mice developed autoimmune-like symptoms, possibly relating to impaired clearance of apoptotic cells by peritoneal macrophages [34]. ERBB2 [35, 36], GRB7 [37, 38], and MIEN1 [39, 40] have all been associated with various carcinomas, affecting cell proliferation and/or cell migration.