PGP and neoplasm: Clinical application, however, has unfortunately shown several limits, such as a high level of neurological and bone marrow toxicity and the emergence of drug-resistant tumor cells due to the overproduction of P-glycoprotein (Pgp), an ATP-binding cassette (ABC) transmembrane transporter [8], the overexpression of different beta-tubulin isotypes, including βIII-tubulin [9, 10], or tubulin mutations [11].