JAK3 and neoplasm: Other apigenin targets were identified inbreast cancer cells, including proteins supporting the growth and survival ofthe tumor: PI3K/ Akt [40], STAT3 [33], NF-κB [34], p53 [34, 41], p21 [41], JAK3 [42], cyclinsD1, D3, and Cdk4 [43]and VEGF [44].