ERBB2 and neoplasm: The transmembrane receptor HER2 is overexpressed in 20–30% of breast andovary tumors [7, 8].High level of HER2 expression usually correlates withaggressive tumor phenotype and enhanced metastasis [9].Because HER2 is expressed at relatively low levels innormal epithelial cells, it makes this receptor an attractive target in cancertherapy.