TNF and pulmonary emphysema: In a murine model of elastase-induced pulmonary emphysema, we found that LASSBio-596: (1) improved elastic recoil, as observed by the decrease in hyperinflation and mean linear intercept; (2) decreased collagen fiber content and TGF-β levels in animals with experimental emphysema; (3) despite not acting on the percentage of total mononuclear cells, blunted the M1 phenotype; (4) reduced levels of TNF-α, IL1-β, IL-6 in lung tissue; and (5) increased VEGF levels in lung tissue.