As Protein kinase C (PKC) activates AC2 by phosphorylating it on Thr-1057 (Böl et al., 1997), another alternative, but more restrictive one to activate AC, relies on the use of Phorbol 12-myristate 13-acetate (PMA) a phorbol diester and a potent tumor promoter known to activate PKC signaling. This evidence concerns the gene PRRT2 and neoplasm.