Given this background recent data on an enhancement of BACE1 expression of hypometabolic neurons (Zhang et al., 2010) made me ask if amyloid Aß, cut from ubiquitous amyloid precursor protein (APP) by ß-secretase BACE1 and γ-secretase, may spot wise induce neuronal cell death via opening ubiquitous VDAC-1 in cell membranes of critical brain regions - a process ending in Alzheimer Disease (Thinnes, 2010, 2011). Here, APP is linked to early-onset autosomal dominant Alzheimer disease.