Cognitive performance, cortical amyloid deposition, hippocampal atrophy, hypometabolism in the parietotemporal cortex, and alteration in the cerebrospinal fluid (CSF) levels of 42-aminoacid amyloid beta peptide (Aβ42), tau, and phosphorylated tau (p-tau) proteins have been consistently associated with higher conversion rates from MCI to AD dementia (Brooks and Loewenstein, 2010; Heister et al., 2011; Barnes et al., 2014). This evidence concerns the gene MAPT and Atrophy.