Although there are exceptions (Quinn et al., 1989; Imai and Narabayashi, 1990; Molinuevo et al., 2003), most pathological studies consistently suggest that pure akinesia is associated with progressive supranuclear palsy (PSP)-tau pathology (Matsuo et al., 1991; Imai et al., 1993; Mizusawa et al., 1993; Riley et al., 1994; Yoshikawa et al., 1997; Compta et al., 2007; Williams et al., 2007). This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.