The role of GPR91 is best studied for kidneys where the succinate-dependent expression of GPR91 involves the renin-angiotensin system and promotes development of renovascular hypertension, which is closely associated with atherosclerosis, diabetes, and renal insufficiency (He et al., 2004; Correa et al., 2007; Sadagopan et al., 2007; Sapieha et al., 2008; Toma et al., 2008; Vargas et al., 2009; Kermorvant-Duchemin et al., 2010; Deen and Robben, 2011). The gene discussed is SUCNR1; the disease is renovascular hypertension.