Mounting evidence has documented a role for PTEN in disorders of nervous system function, including ataxia (Backman et al., 2001), seizures (Backman et al., 2001), mental retardation (Varga et al., 2009; McBride et al., 2010), and autism (Varga et al., 2009; Zhou and Parada, 2012). Here, PTEN is linked to autism.