While untreated PCa specimens only display the modest GR levels (Yemelyanov et al. 2007, Szmulewitz et al. 2012), androgen ablation therapy or chemotherapy result in upregulation and nuclear localization of the GR (Szmulewitz et al. 2012, Yemelyanov et al. 2012), suggesting the functional involvement of the GR in PCa therapy resistance. Here, NR3C1 is linked to posterior cortical atrophy.