SQSTM1 and hyperinsulinemic hypoglycemia, familial, 4: Moreover, aberrant accumulation of Sqstm1-positive aggregated structures has been detected in patients with liver disorders including non-alcoholic steatohepatitis and α1-antitrypsin deficiency, tumors such as hepatocellular carcinoma and various neurodegenerative diseases (Zatloukal et al., 2002).