Activating mutations in epidermal growth factor receptor (EGFR) and KRAS are important markers in non-small cell lung cancer.However, EGFR and KRAS gene mutations in lung squamous cell carcinoma are rarely reported.The aim of this study was to analyze EGFR and KRAS gene mutation rate and their relationship with clinical features in patients with lung squamous cell carcinomas. This evidence concerns the gene EGFR and squamous cell lung carcinoma.