In a number of human malignancies, subpopulations that possess CSC-like properties have been isolated from fresh tumor tissues and permanent cell lines by cell-sorting using the putative CSC-specific markers currently available for this purpose, e.g., CD34, CD44, CD133, ALDH1, EpCAM, and CD271 [1, 7, 8, 10–15]. Here, CD44 is linked to neoplasm.