Other than in SP cells, increased migration and/or invasion capacities have also been observed in oral cancer stem-like cell populations enriched through sphere formation in serum-free cultivation, which showed high expression of Oct3/4, Nanog, and ABCG2 [79], as well as in CD44+ cell populations of HNSCC cells isolated by cell sorting [19]. This evidence concerns the gene NANOG and head and neck squamous cell carcinoma.