TRPC1 and infection: A similar but in-opposite-direction involvement of TRPC1-mediated Ca2+ entry in TLR-mediated inflammation has been demonstrated in microglia and macrophages from mice intracranially inoculated with a helminth Mesocestoides corti [33, 34]; it has been known that humans infected with a related helminth cestode Taenia solium have immunosuppressive rather than inflammatory responses in the asymptomatic phase after the infection.