CXCL8 and neoplasm: One possible explanation is that a relatively increased number of circulating neutrophils produced and secreted angiogenesis-regulating growth factors, chemokines and proteases (e.g., vascular endothelial growth factor (VEGF) [30], interleukin-8 (IL-8) [31], intercellular adhesion molecule 1 [32] and matrix metalloproteinase (MMP)) [33] which may promote tumor growth and metastasis resulting in poor prognosis.