At 6–8 weeks post-infection, these mice displayed a median viremia level of 4.5 × 108 HBV DNA copies/ml (range 1.7 × 107 to 9.4 × 108 copies/ml) and were randomly assigned to different groups (n = 3–4) and injected i.v. with AAV8 vectors expressing GL2, S1, or P28 (1 × 1012 vg per mouse) or with vectors expressing S1 and P28 (each 5 × 1011 vg per mouse), then serum samples were collected weekly to measure HBV titer. Here, PSMD1 is linked to infection.