Such alterations may be upregulations, as in the case of HS3ST1 and HS3ST3A1 in, respectively, hepatocellular cancer and glioblastoma [79, 80], or subexpressions in, for example, HS3ST2 in breast, colon, lung and pancreatic cancers [22], HS3ST1 and HS3ST3A1 in chondrosarcoma cells and HS3ST4, HS3ST5 and HS3ST6 in invasive breast ductal carcinomas [81, 82]. Here, HS3ST5 is linked to familial pancreatic carcinoma.