SDC4 and colon carcinoma: However, a study analyzing mRNA transcripts of syndecan-1 did not find significant differences between normal and cancerous tissues [39], while another, using colon carcinoma cells, evidenced a decrease in syndecan-1 mRNA levels in most of samples, along with a 2–5 fold increase in syndecan-2, and a decrease in syndecan-4 mRNA which was restricted to highly metastatic cell lines [18].