In previous studies of CRCs, a number of changes have been described: a gradual increase in chondroitin polymerizing factor with advancing cancer stage; an increase in CHSY1 expression in normal tissue adjacent to benign tumors compared to tumoral tissues and high expression levels during the early stages; and low expression levels of CHSY3 in both normal and tumor specimens, although it must be stressed that these studies involved colorectal cancers from different locations and not only right sided CRCs [72]. This evidence concerns the gene CHSY3 and benign neoplasm.