That said, all genes whose expression was altered in metastatic CRCs also showed altered expression in non-metastatic tumors, the only exceptions being syndecan-1 and CHPF. The variations observed seem to have a strong effect on CS chains; in non-metastatic tumors they affect most of the GTs responsible for the polymerization of the saccharide chains as well as having an effect on many enzymes involved in their modification. Here, SDC1 is linked to metastatic neoplasm.