As such, p53 has been described to be involved in the regulation of genes such as SULF2 or heparanase [4, 5]; MUC1 and HSPGs cooperate in cell-cell dissociation and the invasiveness of colon carcinoma cells [6]; many members of the TGF-beta cytokine superfamily bind to heparan sulfate (HS) chains [7]; the Wnt/β-catenin pathway is regulated by glypican-3 and—4 [8, 9]; and HSPGs regulate the activity of VEGF, EGF, and other markers related with CRC [10, 11]. Here, HPSE is linked to colon carcinoma.