Some alterations in expressions of colon cancer HSPGs have been described, including alterations which affect the core proteins, as is the case of some syndecans [18], the relative amounts and structure of the GAGs [19, 20], or the expression levels of certain enzymes responsible for the structure of HS saccharidic chains, including glycosyltransferases as EXTL3 [21] or sulfotransferases as 3-OST-2 [22]. This evidence concerns the gene SDC1 and colonic neoplasm.