Along colorectal adenoma-carcinoma progression, the following genes showed downregulation: BCL2, CDX1, ENTPD5, MAL, PRIMA1, PTGDR, SFRP1, and SULT1A1 while the following genes showed upregulation: ALDH1A3, COL1A2, CYP27B1, FADS1, PTGS2, SFRP2, SOCS3, SULF1, THBS2, and TIMP1. Gene expression alteration of BCL2, CDX1, CYP27B1, ENTPD5, MAL, PRIMA1, PTGDR, PTGS2, SFRP1, SOCS3 SULT1A1, and TIMP1 were found to be significant (p < 0.05) in the adenoma versus healthy and also in the tumour versus healthy comparison. The gene discussed is ENTPD5; the disease is colorectal adenoma.