NR1H4 and hyperinsulinemic hypoglycemia, familial, 4: However, the lack of major differences in response of WT-PCLS and FXRKO-PCLS to CsA seems to be in contrast to findings of Wang and colleagues who demonstrated that Fxr-deficiency in Fxr-KO mice and human hepatocytes have significantly increased hepatotoxicity upon exposure to other inducers of oxidative stress represented by carbon tetrachloride (CCl4) and hydrogen peroxide (H2O2) respectively [33].