While autoantibodies to four of the six Sjögren’s/systemic lupus erythematosus antigens tested (RNP-A, RNP-70, Sm-D3, and La), were also seronegative, a few patients exhibited elevated autoantibodies against Ro52 and Ro60. This evidence concerns the gene SNRPD3 and systemic lupus erythematosus.