Mutations in BRCA1, BRCA2, and PALB2 could be implicated because of the young age of onset of breast cancer; while BRCA1 mutations are not associated with WT or Hodgkin’s lymphoma (HL), bi-allelic mutations of BRCA2 and PALB2 cause Fanconi Anemia type D1 and Fanconi anemia type N, respectively, of which WT is an associated clinical feature. This evidence concerns the gene PALB2 and breast cancer.