With regard to the relationship between FBXW7 and HL development, less we can infer from the literature; we know of the involvement of FBXW7 in several forms of acute leukemias20, mainly T-cell (T-ALL), as also demonstrated by conditional FBXW7–/– knockout models in bone marrow and in T cell lineage developing T-ALL and, thymic lymphoma, respectively2. This evidence concerns the gene FBXW7 and Hodgkins lymphoma.