EGFR and non-small cell lung carcinoma: Four RCTs presented data on ORR, which compared the intercalated combination of chemotherapy and EGFR TKIs to chemotherapy alone for the first-line treatment of NSCLC, and no difference in ORR was found (RR = 1.63, 95% CI: 0.97–2.72, P = 0.063) (Fig. 3).