For example, a PB screen identified recurrent transposon insertions in a 200-kb noncoding region (Ncruc) upstream of the Cdkn2a gene [32], which encodes the tumor suppressors p16Ink4a and p19Arf and is frequently inactivated by prototypic gene-body insertions in both SB and PB pancreatic cancer screens [24, 32]. The gene discussed is CDKN2A; the disease is familial pancreatic carcinoma.