Using the TAPDANCE tool, Largaespada and colleagues performed a pathway-centric analysis of alterations in Tp53-mutant, EGFR-driven peripheral nerve sheath tumors to identify roles for the phosphoinositide 3-kinase (PI3K)-AKT-mTOR, mitogen-activated protein kinase (MAPK) and Wnt/β-catenin pathways in the development of this tumor type [56]. Here, TP53 is linked to neoplasm.