Indeed, transposon-insertion-mediated loss of Apc appeared to be a prerequisite for colon tumorigenesis in the Apcmin, KrasG12D and Tp53R172H backgrounds, whereas insertions in Kras and Tp53 are rare in Apc-loss-driven CRC [51] (Table 1; Fig. 4). This evidence concerns the gene APC and colorectal carcinoma.