Furthermore, we showed that mice genetically ablated for PINK1 developed significantly larger myocardial infarcts following an episode of sustained 35 minutes of regional ischemia and 30 minutes of reperfusion compared to their wild-type counterparts, while mice heterozygous for PINK1 had intermediate infarct sizes (Siddall et al., 2013). Here, PINK1 is linked to ischemia.