LMP1 can enhance transwell migration of NPC cells to fibronectin, which may be mediated by enhanced intercellular and ECM interactions.8 In addition, loss of E-cadherin and plakoglobin contributes to LMP1-induced motility in multiple epithelial cell lines.3, 8, 14, 15, 21 To determine if LMP1 enhances MCF10a migration with the potential contribution of N-cadherin and integrins, transwell migration to fibronectin was assessed in the presence of neutralizing antibodies to N-cadherin, integrin-α5 or -αV. The gene discussed is CDH2; the disease is nasopharyngeal carcinoma.