It is postulated that the switch to metastatic outgrowth is mediated by ECM proteins, integrin activation and actin stress fiber remodeling.47, 48 Fibronectin is associated with poor prognosis in multiple types of epithelial cell malignancies and is also induced in NPC in association with EMT markers.49, 50 In this study, the enhanced response of LMP1-expressing cells to fibronectin and the induction of EMT could potentially indicate a physiologically relevant role for fibronectin in the metastatic phenotype of NPC. The gene discussed is PDLIM7; the disease is nasopharyngeal carcinoma.