FN1 and nasopharyngeal carcinoma: LMP1 induces a cadherin switch and promotes the migration of the NPC cell line C666-1.8, 14 To investigate the activity of LMP1 in a non-cancerous cell line, LMP1 was stably expressed by retroviral transduction in MCF10a cells, a cell line susceptible to EMT inducers such as transforming growth factor-β.26 In contrast to the epithelial morphology of pBabe vector control cells, LMP1 expression induced an ECM-independent elongated mesenchymal morphology on uncoated and fibronectin-coated surfaces (Figure 1a).