The protein encoded by BRINP1 is thought to be a critical regulator of tumorigenesis: in cultured breast cancer cells it can modulate the activities of the key receptors ERA, RARA and AR [33] whereas in a bladder tumour cell line it clustered with several proteins in the urokinase-plasminogen pathway involved in inflammation [50]. The gene discussed is RARA; the disease is breast carcinoma.