ERBB2 and gastric adenocarcinoma: In the TOGA study, Bang and colleagues demonstrated survival benefit using the HER-2 monoclonal antibody trastuzumab over placebo with capecitabine/5-FU and cisplatin chemotherapy in patients with advanced gastro-esophageal junction or gastric adenocarcinomas overexpressing HER-2 by immunohistochemistry or HER-2 gene amplification by FISH [11].