Among its defensive mechanisms, SEB forms the most important one because of several reasons such as (a) most potent toxin capable of crossing gastro-intestinal barrier; (b) possible to aerosolize the toxin which also implies that SEB can be made into biological weapon; (c) ingestion of even at nanogram levels cause staphylococcal infections in children and (d) enterotoxins are heat resistant. Here, SETBP1 is linked to staphylococcal infection.