We selected inflammatory (TNF-α and ICAM-1), angiogenic (VEGF and HIF), proliferative (CYCLIN D and c-MYC), oxidative stress (c-MYC), fibrotic (CTGF), and Wnt inhibitory (AXIN2) markers to determine the molecular profile in AMD. The gene discussed is CCN2; the disease is age-related macular degeneration.