At the protein level, phosphorylated LRP6 (p-LRP6) and non-phosphorylated β-catenin (np-b-catenin) were elevated in the retinas of Ccl2−/−/Cx3cr1−/−/rd8 compared to B6N (Fig. 3a, 3 lanes on the left for B6N and 3 lanes in the middle for Ccl2−/−/Cx3cr1−/−/rd8; Fig. 3b, quantitative analysis), suggesting that the Wnt/β-catenin pathway might contribute to the AMD-like lesion. The gene discussed is LRP6; the disease is age-related macular degeneration.